In the last two decades, Kayser Italia achieved a long record of successes in space flight missions. Several Facilities have been designed, developed and flown for Space Life Science to support scientists in investigating the effects of microgravity and radiation on Biological Systems and in Human Physiology. They consist of biology incubators, exobiology facilities, and instruments for human physiology science. The whole set of Facilities is presented, with a comprehensive introduction to the conceptual design tailored towards the experiment requirements and protocols.